https://journalajrre.com/index.php/AJRRE/issue/feed 2024-04-19T10:50:07+00:00 Asian Journal of Research and Reports in Endocrinology contact@journalajrre.com Open Journal Systems <p style="text-align: justify;"><strong>Asian Journal of Research and Reports in Endocrinology</strong>&nbsp;aims to publish&nbsp;high-quality&nbsp;papers (<a href="/index.php/AJRRE/general-guideline-for-authors">Click here for Types of paper</a>) in all aspects of&nbsp;‘Endocrinology’. By not excluding papers based on novelty, this journal facilitates the research and wishes to publish papers as long as they are technically correct and scientifically motivated. The journal also encourages the submission of useful reports of negative results. This is a quality controlled, OPEN peer-reviewed, open-access INTERNATIONAL journal.</p> https://journalajrre.com/index.php/AJRRE/article/view/86 2024-02-22T10:21:25+00:00 Manjula S drmanjulas@gmail.com Krishna Kumar M

<p><strong>Background:</strong> Diabetes mellitus is a prevalent disease, and its burden has increased over the years which is going to cross 134 million cases by 2045, despite the available treatments. This study was carried out to understand the prescribing behaviours in the management of diabetes.</p> <p><strong>Methodology: </strong>In this cross-sectional study conducted from June 2022 to December 2022, a questionnaire was administered to clinicians focused on diabetes prevalence, symptoms, causes, clinical characteristics, and the utilization of different antidiabetic medications. The data collected was analysed using descriptive statistics.</p> <p><strong>Results:</strong> Around 353 clinicians responded with the majority from Delhi (8.8%). The most commonly preferred first-line drug is metformin (46.5%). Vildagliptin (89%) is the most preferred drug out of the DPP-4 inhibitors that is added to metformin to achieve glycaemic control. Dapagliflozin (87%) is the most preferred SGLT-2 inhibitor. It was seen that 59.2% opted for DPP-4 inhibitor and SGLT-2 inhibitor FDC in 25 to 50% of their diabetic patients. If affordability was not an issue most clinicians (44.2%) preferred vildagliptin, dapagliflozin, and metformin FDC. Insulin usage declined with 38.8% reporting that they used insulin in only 11 to 15% of their diabetic patient pool and 71.4 % reported hypertension as the most common comorbidity with diabetes.</p> <p><strong>Conclusion:</strong> This study gives a comprehensive view of the perspectives of the medical community with respect to evidence-based change in management trends which will help make strategies to improve patient outcomes. It also sheds light on factors clinicians consider to choose treatment options. One criterion that is as important as efficacy and safety is affordability.</p>

2024-02-22T00:00:00+00:00 Copyright (c) 2024 Author(s). The licensee is the journal publisher. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. https://journalajrre.com/index.php/AJRRE/article/view/88 2024-03-16T12:49:31+00:00 Casimir C. Ofor trendicas@gmail.com Eugene O Ohanme Uzochukwu Ofonakara Benjamin N Nwakelu Samuel I Ghasi

<p>A lot of significant studies carried out in the past demonstrated the beneficial effects of walnuts (<em>Juglans regia</em>) in clinical patients diagnosed with type 2 diabetes mellitus (T2DM). There are however some contradictions in the findings of the studies done. In this review, a search of some online databases (PubMed and Google scholar) was carried out to isolate some studies that examined the role of walnuts on glycaemic indices in type 2 diabetes mellitus. A randomized, cross over study recently found an increase in post-meal energy expenditure, but no difference in satiety between subjects fed walnuts versus fat-rich dairy products. This was based on reported appetite satisfaction after one meal in an outpatient setting. Other relevant studies showed that walnut extracts markedly lowered fasting blood glucose (FBS) and HBAIC and increased the insulin level in diabetic patients at the end of their study. The mechanism behind the hypoglycemic activity of walnuts could be due to increase in insulin release from remnants of β-cells in the pancreas, its antioxidant properties, the restoration of insulin sensitivity and interference with the absorption of dietary carbohydrates in the small intestine. The reported hypoglycemic effect of <em>juglans regia</em> may also be due to the presence of phenolic acids (gallic acid and caffeoylguinic acid) in walnuts. Various studies have shown that walnuts consumption could markedly reduce the incidence of type 2 diabetes mellitus in the population.</p>

2024-03-16T00:00:00+00:00 Copyright (c) 2024 Author(s). The licensee is the journal publisher. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. https://journalajrre.com/index.php/AJRRE/article/view/89 2024-04-04T13:28:18+00:00 Ogwo Elisha Uko ogwoelisha@gmail.com Ejiofor Dominic Chinedu Obioma Elizabeth Nweke Ubani Clement Dimgba Iheukwumere Barry Chinedu

<p>The aim of this study was to evaluate the biochemical changes in diabetic Wistar rats administered methanol leaf extract of <em>Andropogon gayanus</em>. Freshly harvested leaves of <em>A. gayanus</em> were processed into extract. Twenty-five adult male Wistar rats were divided into five groups of five rats per group. <strong>Group I</strong> was the normal control and was administered 2 mL of distilled water. <strong>Group II</strong>: was induced diabetes without treatment. <strong>Group III:</strong> were diabetic rats treated with 100 mg/kg of <em>A. gayanus</em> leaf extract. <strong>Group IV:</strong> was diabetic rats treated with 200 mg/kg of <em>A. gayanus</em> leaf extract. <strong>Group V: </strong>was diabetic rats treated with standard drugs. The activities of AST, ALT and ALP in diabetic groups treated with the aforementioned extract were significantly (P&lt;0.05) lower than those reported for the normal control. However, a contrary observation was made on the serum albumin and total protein. Total cholesterol (TC) and Triglycerides as well as Low-Density Lipoprotein reported for groups treated with extract were significantly (P&lt;0.05) higher than those reported for the negative control. However, a contrary observation was made on the High-Density Lipoprotein (HDL). Serum creatinine and urea reported for the negative control were significantly (P&lt;0.05) higher than those reported groups administered leaf extract of <em>Andropogon gayanus</em>. In conclusion, it can be deduced from this study that methanol leaf extract of <em>Andropogon gayanus </em>has influence on the indices evaluated which can be traced to the biological activities of certain active ingredients inherent in them.</p>

2024-04-04T00:00:00+00:00 Copyright (c) 2024 Author(s). The licensee is the journal publisher. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. https://journalajrre.com/index.php/AJRRE/article/view/90 2024-04-19T10:50:07+00:00 Dilara Bulut Gökten dilarabulutgokten@gmail.com Gülsüm Kübra Bahadir Amed Trak Lale Damgaci Ihsan Ateş

<p><strong>Objective: </strong>The study focused on elucidating the presence of pancreatic steatosis in pre-diabetes and diabetes mellitus along with investigating the correlation between pancreatic steatosis and metabolic parameters.</p> <p><strong>Methods: </strong>This research involved 314 patients who sought treatment at internal medicine outpatient and inpatient clinics from April 2022 to May 2023. Patients who underwent non-enhanced abdominal computed tomography for any reason were included in the study. The patients were categorized into three groups: healthy controls(n=103), diabetes individuals(n=109), and prediabetes individuals(n=102).</p> <p><strong>Results: </strong>The study aimed to explore the relationship between pancreatic steatosis and metabolic parameters. The findings revealed that HDL level, albumin, and glomerular filtration rate (GFR) showed a positive correlation with pancreatic density, indicating a lower degree of steatosis in the pancreatic tissue. Conversely, patients with higher levels of HbA1c, uric acid, blood glucose levels, body mass index, INR exhibited a higher degree of pancreatic steatosis.</p> <p>Furthermore, the research identified the presence of pancreatic steatosis in prediabetes patients. There was no significant difference in pancreatic steatosis between prediabetes and diabetes patients, suggesting that their pancreatic densities were statistically similar(p=0,08).</p> <p><strong>Conclusion: </strong>Our study investigated pancreatic steatosis in diabetes and pre-diabetes patients, and its relationship with metabolic parameters.The findings suggest that pancreatic steatosis is also present in the prediabetes phase and it has a correlation with metabolic parameters seen in diabetes process.</p>

2024-04-19T00:00:00+00:00 Copyright (c) 2024 Author(s). The licensee is the journal publisher. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. https://journalajrre.com/index.php/AJRRE/article/view/87 2024-03-16T08:08:48+00:00 Akhidue, K. Amadi, ES ekechiamadi@yahoo.com Batubo, UD Gomba, VE

<p><strong>Background: </strong>Thyroid disorders in the elderly commonly occur as hypothyroidism but hyperthyroidism can also occur. Diagnosing thyroid disorders in the elderly can be difficult due to varying factors.&nbsp; Among these is the age related decline of function of organ systems and the presence of morbid conditions in the elderly that often require medications some of which affect thyroid hormone metabolism. Subclinical hyperthyroidism is often the presentation rather than overt hyperthyroidism hence combining the physical presentation and thyroid investigations of an aged patient may be more useful in making effective clinical judgment.</p> <p><strong>Aim: </strong>The aim of this case report is to show the variety of ways in which hyperthyroidism can present in the older adult.</p> <p><strong>Methods:</strong>&nbsp; Relevant clinical and biochemical data was retrieved from the case notes of 3 older adults who presented with clinical and biochemical evidence of hyperthyroidism to the University of Port Harcourt Teaching Hospital, Port Harcourt, Nigeria from 2015 to 2022.</p> <p><strong>Conclusion:</strong> Hyperthyroidism in the elderly can present in variety of ways which may be different from the typical way in other age groups. The biochemical findings may not be clear cut in making diagnosis hence the need to acquire the clinical skill in combining the physical manifestations with the thyroid investigations.</p>

2024-03-16T00:00:00+00:00 Copyright (c) 2024 Author(s). The licensee is the journal publisher. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. https://journalajrre.com/index.php/AJRRE/article/view/85 2024-02-07T12:51:32+00:00 Albatool Almukairish Aliaa Sabban Khalid Bakheit khalid2_3456@yahoo.com

<p>Hormones have a critical role in regulating a number of body functions, including mood, metabolism, growth and development, and reproductive health. This article covers common hormone disorders, as well as their causes, symptoms, complications, and available treatments. Common treatment modalities for hormone problems include medication, lifestyle modifications, surgery, complementary therapies, and routine monitoring. The course of treatment may also be accompanied by possible negative effects, such as cancer risk, hormone overcorrection, and interactions with other medications or medical conditions. Regular hormone level and symptom evaluations by healthcare professionals are necessary to provide individual treatment plans that lower the risk of complications while achieving the desired therapeutic goals.</p>

2024-02-07T00:00:00+00:00 Copyright (c) 2024 Almukairish et al.; This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.