Asian Journal of Research and Reports in Endocrinology

Evaluation of the Hepatoprotective Activity of Leaf Extracts of Mimosa Pudica on Wistar Rats

Mas’-Ud Hayatou

Department of Pharmacotoxicology and Pharmacokinetics, Faculty of Medicine and Biomedical Sciences, University of Yaoundé 1, Cameroon.

Estella Achick Tembe

Department of Pharmacotoxicology and Pharmacokinetics, Faculty of Medicine and Biomedical Sciences, University of Yaoundé 1, Cameroon.

Bayaga Herve

Department of Pharmacognosy and Pharmaceutical Chemistry, Faculty of Medicine and Biomedical Sciences, University of Yaoundé 1, Cameroon.

Njinkio Nono Borgia

Department of Pharmacotoxicology and Pharmacokinetics, Faculty of Medicine and Biomedical Sciences, University of Yaoundé 1, Cameroon.

Charles N. Fokunang *

Department of Pharmacotoxicology and Pharmacokinetics, Faculty of Medicine and Biomedical Sciences, University of Yaoundé 1, Cameroon.

*Author to whom correspondence should be addressed.

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Abstract

The liver is an important metabolic organ of the body that can be subjected to conditions with serious repercussions. The management of hepatic pathologies is very often complex and sometimes requires transplants, hence the interest in the development of new strategies, including plant-based drugs to address liver related challenges. Mimosa pudica, of the Mimosaceae family, has been described in Ayurvedic medicine for treating many ailments and moreover liver disease which is the aim of this study. After performing an extraction following the standard procedures, an in vivo evaluation of the hepatoprotective activity of M.pudica leaf extracts on Wistar rats was conducted using standard assays, which consisted of the dosage of biochemical parameters such as Aspartate amino transferase (AST), Alanine amino transferase (ALT), Alkaline phosphate (AP), Creatinine, total proteins, total cholesterols, triglycerides, albumin, high density lipoproteins-cholesterol (HDL-cholesterol), low density lipoproteins-cholesterol (LDL-cholesterol) uric acid, albumin, urea, malondialdehyde (MDA), Superoxide dismutase (SOD), Glutathione, Catalase and histopathological analysis of rat’s liver. Analysis of biochemical parameters showed a significant reduction in the liver damage in rats treated with M. pudica leaf extracts, and less marked liver damage as compared to the positive control group was a promising indicator of hepatoprotection. Histopathology analysis showed no observable damage of organs treated with the plant extracts.

Keywords: Mimosa pudica, hepatoprotection, leaf extract, wistar rats

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