Evaluation of the Anti-Diabetic Potential of Ethanol Extract of Persea americana Fruit Peel (Pericarp)
Published: 2022-08-29
Page: 146-149
Issue: 2022 - Volume 5 [Issue 1]
C. D. Ubani *
Department of Human Physiology, College of Medicine and Health Sciences, Abia State University, Uturu, Nigeria.
A. K. Amah
Department of Human Physiology, Imo State University, Owerri, Nigeria.
K. C. Obioha
Department of Pediatrics, Federal Medical Centre, Owerri, Imo State, Nigeria.
M. U. Elendu
Department of Human Physiology, Imo State University, Owerri, Nigeria.
*Author to whom correspondence should be addressed.
Abstract
The aim of this study was to evaluate the anti-diabetic potential of ethanol extract of P. americana fruit peel (Pericarp). Peel obtained from ripe avocado fruits was thoroughly washed with clean tap water, dried at room temperature before being ground to fine powder after which extract was developed. Fifteen (15) adult male wistar rats were divided into three (3) groups of five (5) rats each. Group I was the normal control fed rat chow and water ad-libtum, Group II was the diabetic control and was not treated with the extract, while Group III was diabetic rats treated with 100 mg/kg of P. americana fruit peel extract for 21 days. Blood glucose level was determined weekly through standard procedures. The results obtained revealed that administration of alloxan monohydrate significantly (P<0.05) raised blood glucose level in rats. However, administration of P. americana fruit peel extract significantly (P<0.05) reduced blood glucose level in diabetic rats. In conclusion, this works established the anti-diabetic potential of the fruit peel of P. americana.
Keywords: Persea americana, glucose, pericarp, fruit, diabetes mellitus