Asian Journal of Research and Reports in Endocrinology

Endocrine Dysfunctions in Renal Tubular Disorders

Nelisa Rodriquez

All Saints University, College of Medicine, Saints Vincent and the Grenadines, Dominica.

Sai Erambalur

All Saints University, College of Medicine, Saints Vincent and the Grenadines, Dominica.

Sarah Izuchukwu

All Saints University, College of Medicine, Saints Vincent and the Grenadines, Dominica.

Adijat Oyewole

All Saints University, College of Medicine, Saints Vincent and the Grenadines, Dominica.

Daniel Okundaye

All Saints University, College of Medicine, Saints Vincent and the Grenadines, Dominica.

Adedeji Okikiade *

All Saints University, College of Medicine, Saints Vincent and the Grenadines, Dominica.

Damisola Ogunesan

Lagos State University, Teaching Hospital, Idi-Araba, Lagos, Nigeria.

*Author to whom correspondence should be addressed.

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Abstract

This is a review article with narratives on a rare discussion of existence of hormonal dysfunctions in variants of renal tubular acidosis (RTA), acquired and congenital renal tubular disorders, with focus on the molecular and physiological defects. The renal tubules primarily function in excretion of hydrogen ions and filtration of bicarbonates, and any form of damage may interfere with this functions and subsequently lead to chronic kidney disease. There are myriads of causes of renal tubular disease with subsequent development of hormonal abnormalities. The aim is to explore existing literatures and knowledge in understanding the hormonal changes associated with various renal tubular disorders, highlighting different renal tubular disorders like Fanconi’s syndrome, Liddle’s disease, Barter’s syndrome, and Gittelman’s syndrome, elucidate the molecular and pathophysiological basis of various renal tubular disorders and associated endocrine disorders. Articles/literatures’ are selected using keywords below and searching various literatures and books on the internets for common renal tubular disorders. This is part of students project aim to teach and improves integration and interactive learning process in Pathophysiology.

Keywords: Renal system, renal tubular acidosis, renal tubular disorders, proximal convoluted tubule, distal convoluted tubule, loop of henle, collecting ducts, endocrine hormones

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