Effect of Co-administration of Aqueous Musa acuminata cavendish and Allium sativium Extracts on Streptozotocin - Induced Type 2 Diabetes on Wistar Rat
Ejim Nnamdi Ferdinand
Department of Human Physiology, Faculty of Basic Medical Sciences, College of Medicine, Enugu State University of Science & Technology, Enugu, Nigeria.
Ani Celestine Okafor *
Department of Human Physiology, Faculty of Basic Medical Sciences, College of Medicine & Health Science, Rhema University Aba, Abia State, Nigeria.
Onah Emmanuel
Department of Ophthalmology, David Umahi Federal University of Health Sciences, Uburu, Ebonyi State, Nigeria.
Okeke Adaobi Pearl
Department of Human Physiology, Faculty of Basic Medical Sciences, College of Medicine, University of Nigeria, Enugu Campus, Enugu State, Nigeria.
Uzoefuna Casmir Chima
Department of Medical Biochemistry, Faculty of Basic Medical Sciences, College of Medicine, State University of Medical and Applied Sciences, Igbo Eno, Nsukka, Enugu State, Nigeria.
Nweke Luke Maduka
Department of Human Physiology, Faculty of Basic Medical Sciences, College of Medicine, University of Nigeria, Enugu Campus, Enugu State, Nigeria.
*Author to whom correspondence should be addressed.
Abstract
This study investigated the effects of Musa acuminata Cavendish and Allium sativum aqueous extracts, both individually and in combination, on streptozotocin-induced type 2 diabetes in Wistar rat. A total of thirty (30) male Wistar rats were used in this study and were divided into six groups of five (5) rats each viz, A, B, C, D, E and F (where group A =Normal control group, B= diabetic untreated, C= diabetic + treated with Musa acuminata extract, D= Diabetic + with Allium sativum extract, E=Diabetic + with a combination of both extracts, F= Diabetic + treated with glibenclamide. Blood glucose levels, body weight, and histopathological changes in liver tissues were measured and analyzed. Both Musa acuminata and Allium sativum extracts significantly (P<0.05) caused a decrease in the blood glucose levels, compared to group B. Group E exhibited the most efficacy and potency in terms of hypoglycemic effect, suggesting a synergistic interaction. Treated groups also showed improved body weight maintenance and normalized food and water intake patterns. Histopathological analysis revealed reduced damage to pancreatic tissues in the treated groups, especially in the combination group and glibenclamide induced group respectively. The study indicates that the co-administration of Musa acuminata and Allium sativum extracts can be used effectively in the management of patients with hyperglycemia. The observed benefits are likely due to the antioxidant and anti-inflammatory properties of the extracts, as well as their ability to modulate glucose metabolism. The synergistic effects of the combination therapy highlight the potential for developing multi-component herbal treatments for diabetes.
Keywords: Musa acuminata cavendish, streptozotocin, diabetes, Allium sativium